NAD + 500mg

NAD+ 500mg: Essential Cellular Coenzyme

Nicotinamide Adenine Dinucleotide (NAD+) is a critical coenzyme found in every living cell. It serves as a fundamental component in energy metabolism and cellular signaling. In research models, NAD+ is central to the study of mitochondrial function, DNA repair, and the biological processes of aging.

Research Highlights

• Mitochondrial ATP Production: Functions as a key electron carrier in the oxidative phosphorylation pathway, directly influencing the efficiency of cellular energy production.

• Sirtuin Activation: Acts as an essential substrate for sirtuins (SIRT1-7), a family of "longevity proteins" that regulate gene expression, stress resistance, and metabolic homeostasis.

• DNA Repair Mechanism: Serves as a necessary cofactor for PARP (Poly-ADP Ribose Polymerase) enzymes, which detect and repair damaged DNA strands.

• Circadian Rhythm Regulation: Studied for its role in modulating the body's internal clock by influencing the activity of CLOCK-BMAL1 transcriptional complexes.

• Redox Balance: Critical for maintaining the NAD+/NADH ratio, which is a primary indicator of cellular redox state and overall metabolic health.
  

  Molecular Structure & Details

  Unlike peptides, NAD+ is a dinucleotide. It does not have an amino acid sequence. It consists of two nucleotides joined through their phosphate groups: one with an adenine base and the other with nicotinamide.

  • Purity: 99% Pure

  • Form: Lyophilized powder 

  Storage & Stability

  • Lyophilized Powder: Store at -20°C for long-term stability. For immediate use, refrigeration at 2°C – 8°C is acceptable for up to 3 months.

  • Reconstituted Solution: NAD+ is highly sensitive to temperature and light once in liquid form. Store at 2°C – 8°C and use within 24–48 hours for maximum experimental accuracy.

  • Degradation Note: Exposure to light and moisture will cause rapid degradation into nicotinamide and ADP-ribose. Keep vials tightly sealed.