Pt 141 10mg

PT-141 10mg: Synthetic Melanocortin Agonist for Neurological Research

PT-141, also known as Bremelanotide, is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone ($\alpha$-MSH). Developed from the tanning peptide Melanotan II, PT-141 is uniquely distinguished by its ability to modulate the central nervous system (CNS) to influence physiological responses. Unlike traditional research compounds that target vascular pathways, PT-141 acts as a non-selective agonist of melanocortin receptors, primarily targeting the brain's arousal and motivational centers.

Research Highlights

• Central Nervous System Mechanism: Operates directly via the CNS by activating melanocortin receptors (primarily MC3R and MC4R) in the hypothalamus, a key regulatory area for sexual behavior and motivation.

• Neurogenic Arousal Induction: Extensively researched for its ability to bypass peripheral vascular mechanisms to trigger arousal signals, making it a primary subject for studies on hypoactive sexual desire disorder (HSDD).

• Dopaminergic Synergy: Investigations suggest that PT-141 stimulation leads to the release of dopamine in the medial preoptic area, enhancing the "reward" and "appetitive" aspects of behavioral responses.

• Isomer Stability: Utilizes a D-Phenylalanine isomer in its core sequence, which significantly increases its resistance to enzymatic breakdown and enhances its binding affinity compared to natural ligands.

• Comparative Selectivity: While derived from Melanotan II, PT-141 is refined to minimize the melanogenic (tanning) effects while maximizing the neurological signaling pathways.
  

Safety & Research Warning

• RESEARCH USE ONLY: This material is strictly for laboratory research and in vitro testing. It is not for human or veterinary consumption.

• Regulatory Status: MOTS-c is an experimental compound and is not FDA-approved for the treatment of any medical condition.

• Handling: Research must be conducted in a controlled environment. Use appropriate PPE, including gloves and masks, to prevent accidental exposure.

Storage & Stability

• Lyophilized Powder: Stable at room temperature for up to 4 weeks. For long-term storage, keep at -20°C to maintain 99% purity for up to 24 months.

• Reconstituted Solution: After reconstitution with sterile water or bacteriostatic water, store at 2°C – 8°C. Due to the delicate nature of mitochondrial-derived peptides, use within 7–10 days for maximum experimental accuracy.

• Sensitivity: Highly sensitive to bacterial contamination and temperature fluctuations. Do not leave the reconstituted vial at room temperature for extended periods.